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When stavudine is used in combination with other agents with similar toxicities, the incidence of adverse events may be higher than when stavudine is used alone. Pancreatitis, Peripheral neuropathy, and liver function abnormalities occur more frequently in patients treated with the combination of stavudine.

The duration of clinical benefit from antiretroviral therapy may be limited. Patients recieving nevirapine or any other antiretroviral therapy may continue to devleop opportunistic infections and other complications of HIV infection, and therefore should remain under close clinical observation by physicians experienced in the treatment of patients with associated HIV diseases.

Stavudine therapy has rarely been associated with motor weakness, occuring predominantly in the setting of lactic acidosis. The evolution of motor weakness may mimic the clinical presentation of the Guillian-Barre Syndrome(including respiratory failure). Symptoms may continue or worsen following discontinuation of therapy.

Stavudine therapy has also been associated with peripheral sensory neuropathy, which can be severe, is dose related, and occurs more frequently in patients being treated with neurotoxic drug therapy, including didanosine, in patients with advanced HIV infection, or in patients who have previously experienced peripheral neuropathy.

Caregivers of young children recieving stavudine therapy should be instructed regarding detection and reporting of peripheral neuropathy.